ANTITUMOR DRUG SCREENS Meaning and
Definition
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Antitumor drug screens refer to laboratory experiments or assays conducted to evaluate the effectiveness of various compounds or substances in inhibiting the growth and proliferation of tumor cells or to identify potential therapeutic agents for treating cancer. These screens involve systematic testing of numerous chemical compounds, natural products, or synthetic substances to identify those that exhibit antitumor activity.
These screens typically utilize in vitro systems, such as cultured tumor cell lines or tumor cells derived from patients, to assess the effects of the tested substances on the growth and survival of cancer cells. The substances can be administered individually or in combination to observe their cytotoxic effects or the ability to induce tumor cell death, inhibit cell proliferation, or impede the invasion and metastasis of cancer cells. Various cellular and molecular techniques, such as cell viability assays, flow cytometry, gene expression analysis, and protein profiling, may be employed to measure the efficacy of potential antitumor agents.
Antitumor drug screens aim to identify compounds that exhibit potent and selective antitumor activity while minimizing toxicity to normal cells and tissues. The results obtained from these screens serve as a valuable resource for drug discovery and development, providing insights into the mechanisms of action of potential therapeutic agents. Ultimately, the identification and characterization of effective antitumor drugs through these screens can contribute to the advancement of cancer treatment and improve patient outcomes.
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