ANTITUMOR DRUG SCREEN Meaning and
Definition
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Antitumor Drug Screen refers to a laboratory technique or assay used in the field of medical research and drug discovery to identify potential therapeutic agents or drugs that are capable of inhibiting the growth or spread of tumor cells. This screening process involves the systematic testing of a large number of chemical compounds or substances to determine their effectiveness in killing or inhibiting tumor cells.
The antitumor drug screen typically consists of various stages, including the initial testing of compounds using well-established cell lines or cultures derived from different types of tumors. These cells are then exposed to the test compounds in different concentrations or combinations to evaluate their effects on cell viability, proliferation, or apoptosis (programmed cell death). Advanced techniques such as flow cytometry, fluorescence microscopy, or molecular techniques may be employed to analyze these effects.
The objective of an antitumor drug screen is to identify potential drug candidates or compounds that exhibit high potency and selectivity against tumor cells, while displaying minimal toxicity to normal cells or tissues. This screening approach is crucial in the drug development process as it helps identify promising drug candidates for further investigation, optimizing their therapeutic properties, and eventually progressing them to preclinical and clinical trials.
These screens are designed to facilitate the discovery of new anticancer drugs, enhance our understanding of tumor biology and drug resistance mechanisms, and contribute to the development of more effective and targeted therapies for the treatment of cancer.
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