ACUTE PHASE PROTEIN Meaning and
Definition
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Acute Phase Protein:
An acute phase protein refers to a group of proteins that significantly increase or decrease in concentration during acute inflammation or infection. These proteins are synthesized in the liver and play a vital role in the body's response to injury, infection, or tissue damage. The synthesis of acute phase proteins is primarily regulated by cytokines, which are signaling molecules released by immune cells in response to infection or inflammation.
The concentration of acute phase proteins typically changes rapidly following the onset of inflammation or infection. Inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-alpha) stimulate the liver to produce specific acute phase proteins. Examples of acute phase proteins include C-reactive protein (CRP), fibrinogen, haptoglobin, and serum amyloid A.
The function of acute phase proteins varies depending on the specific protein. They can contribute to various physiological processes, including inflammation regulation, tissue repair, immune response modulation, and blood clotting regulation. Acute phase proteins serve as biomarkers in clinical settings, as their concentration levels can help diagnose and monitor various conditions like bacterial and viral infections, autoimmune disorders, and chronic inflammation. Additionally, the measurement of acute phase proteins can provide valuable insight into the severity of the inflammatory response or infection, aiding in treatment decisions and assessing prognosis.
Common Misspellings for ACUTE PHASE PROTEIN
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