TYPE X COLLAGEN Meaning and
Definition
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Type X collagen is a protein that belongs to the collagen family and is primarily found in the extracellular matrix (ECM) of developing cartilage, specifically in the hypertrophic zone. It plays a crucial role in endochondral ossification, which is the process by which cartilage is transformed into bone.
The Type X collagen protein is encoded by the COL10A1 gene and, once synthesized, assembles to form a characteristic triple-helical structure. This collagen is known for its distinctive localization within hypertrophic chondrocytes, where it is mainly present in the form of homotrimers or heterotrimers with other types of collagen. It provides structural support to the developing bone by forming a network of fibers that help to hold the hypertrophic chondrocytes together.
Functionally, Type X collagen is involved in maintaining the integrity and stability of the hypertrophic cartilage matrix during bone development. It promotes chondrocyte maturation and hypertrophy, mainly acting as a substrate for mineralization (calcification) of the extracellular matrix. This collagen also regulates the differentiation of chondrocytes into bone cells, known as osteoblasts, and has been implicated in promoting angiogenesis in the adjacent tissues.
In summary, Type X collagen is a specialized form of collagen that plays a crucial role in the development of bone from cartilage. Its unique localization and functions make it an essential protein for endochondral ossification.
Common Misspellings for TYPE X COLLAGEN
- Typu IX Collagen
- rype x collagen
- fype x collagen
- gype x collagen
- yype x collagen
- 6ype x collagen
- 5ype x collagen
- ttpe x collagen
- tgpe x collagen
- thpe x collagen
- tupe x collagen
- t7pe x collagen
- t6pe x collagen
- tyoe x collagen
- tyle x collagen
- ty-e x collagen
- ty0e x collagen
- typw x collagen
- typs x collagen
- typd x collagen
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