TRANSNEURONAL RETROGRADE DEGENERATION Meaning and
Definition
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Transneuronal retrograde degeneration refers to a type of neuronal cell death that occurs in a pathway of interconnected neurons, where damage to or loss of function in one neuron leads to the degeneration and death of other interconnected neurons in the pathway. This type of degeneration happens in a retrograde manner, meaning that it progresses from the end of the pathway (far from the site of injury or dysfunction) towards the beginning.
The process begins when a neuron within the pathway is injured, becomes dysfunctional, or dies. This event triggers a series of cellular events that ultimately lead to the degeneration and death of other neurons that are connected to the affected neuron. The specific mechanism behind transneuronal retrograde degeneration is not completely understood, but it is believed to involve the spread of toxic substances or molecular signals from the injured neuron to the healthy ones.
Transneuronal retrograde degeneration has been observed in various neurological disorders and injuries, such as strokes, traumatic brain injuries, and neurodegenerative diseases like Alzheimer's and Parkinson's disease. The extent of degeneration and the resulting functional deficits can vary depending on the location and severity of the initial injury, as well as the specific pathways and neurons affected.
Studying transneuronal retrograde degeneration can provide valuable insights into the connectivity and vulnerability of different neuronal circuits, as well as potential targets for therapeutic interventions aimed at preventing or slowing down the progression of neurodegenerative diseases.
Common Misspellings for TRANSNEURONAL RETROGRADE DEGENERATION
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