TACROLIMUS BINDING PROTEINS Meaning and
Definition
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Tacrolimus Binding Proteins (Tbps) are a class of proteins that specifically bind to the immunosuppressive drug tacrolimus, also known as FK506. Tacrolimus is commonly used in medical fields such as organ transplantation to suppress the immune system's response to prevent rejection of transplanted organs. Tacrolimus exerts its immunosuppressive effects by binding to a family of immunophilins, which include Tbps, and forming a complex that inhibits the action of calcineurin, a phosphatase enzyme involved in the activation of T cells.
Tbps play a crucial role in mediating the effects of tacrolimus by binding to the drug and facilitating its interaction with other cellular components. They are primarily found in the cytosol of cells, particularly lymphocytes, which are key players in the immune response. Tbps are highly conserved among various species and are categorized into two main types: FK506-binding protein (FKBP) and FK506-binding protein-like (FKBPL).
These proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity, allowing them to catalyze the interconversion of peptide bonds between the cis and trans orientations. This enzymatic activity contributes to the modulation of protein conformation and function. Additionally, Tbps are involved in signal transduction pathways and interact with several other proteins to regulate various cellular processes, including apoptosis, cell growth, and differentiation.
The binding of tacrolimus to Tbps not only inhibits calcineurin activity but also influences the stability, localization, and function of Tbps themselves. Therefore, understanding the structure and function of Tbps is essential for elucidating the mechanisms of tacrolimus action and developing strategies to enhance its therapeutic effects.
Common Misspellings for TACROLIMUS BINDING PROTEINS
- racrolimus binding proteins
- facrolimus binding proteins
- gacrolimus binding proteins
- yacrolimus binding proteins
- 6acrolimus binding proteins
- 5acrolimus binding proteins
- tzcrolimus binding proteins
- tscrolimus binding proteins
- twcrolimus binding proteins
- tqcrolimus binding proteins
- taxrolimus binding proteins
- tavrolimus binding proteins
- tafrolimus binding proteins
- tadrolimus binding proteins
- taceolimus binding proteins
- tacdolimus binding proteins
- tacfolimus binding proteins
- tactolimus binding proteins
- tac5olimus binding proteins
- tac4olimus binding proteins
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