RAPAMYCIN BINDING PROTEINS Meaning and
Definition
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Rapamycin-binding proteins (also known as FKBP proteins) are a group of intracellular proteins that have a high affinity for binding to the immunosuppressive drug rapamycin. These proteins are found in a wide range of organisms, including bacteria, yeast, plants, and animals.
Rapamycin is a macrolide compound that was originally discovered in the soil bacterium Streptomyces hygroscopicus. It has been extensively studied for its immunosuppressive and anti-cancer properties. Rapamycin-binding proteins play a crucial role in mediating the physiological effects of this drug.
Rapamycin-binding proteins are part of a larger class of proteins called immunophilins. They have a characteristic peptidyl-prolyl cis-trans isomerase (PPIase) activity, which catalyzes the interconversion of cis and trans isomers of peptide bonds formed by proline residues. This isomerization activity is crucial for the proper folding and function of proteins.
The binding of rapamycin to these proteins regulates their activity and leads to a downstream signaling cascade that affects various cellular processes. One of the most well-known targets of rapamycin-binding proteins is the protein kinase mTOR (mammalian target of rapamycin), which regulates cell growth, proliferation, and survival.
Overall, rapamycin-binding proteins play a pivotal role in mediating the biological effects of rapamycin and are an essential component of the cellular response to this immunosuppressive drug. Studying these proteins can provide valuable insights into the mechanisms of action of rapamycin and may have implications for the development of new therapeutic strategies for immune-related disorders and cancer.
Common Misspellings for RAPAMYCIN BINDING PROTEINS
- eapamycin binding proteins
- dapamycin binding proteins
- fapamycin binding proteins
- tapamycin binding proteins
- 5apamycin binding proteins
- 4apamycin binding proteins
- rzpamycin binding proteins
- rspamycin binding proteins
- rwpamycin binding proteins
- rqpamycin binding proteins
- raoamycin binding proteins
- ralamycin binding proteins
- ra-amycin binding proteins
- ra0amycin binding proteins
- rapzmycin binding proteins
- rapsmycin binding proteins
- rapwmycin binding proteins
- rapqmycin binding proteins
- rapanycin binding proteins
- rapakycin binding proteins
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