MULTIPLE NEUROFIBROMA Meaning and
Definition
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Multiple neurofibromas are a type of benign tumor that originates in the peripheral nervous system, specifically from the cells known as Schwann cells which produce the myelin sheath responsible for insulating nerve fibers. This condition is characterized by the presence of multiple neurofibromas scattered throughout the body, affecting various organs and tissues.
Neurofibromas are typically noncancerous growths that develop on nerves or nerve roots and appear as small, soft nodules, often painless and slow-growing. However, in the case of multiple neurofibromas, several of these tumors can manifest simultaneously, leading to a higher number of affected sites within the body. These tumors may involve both peripheral nerves and central nervous system structures.
Genetic mutations in the NF1 gene are primarily responsible for the development of multiple neurofibromas. This condition is strongly associated with neurofibromatosis type 1 (NF1), a genetic disorder that affects around one in every 3,000 individuals worldwide. Multiple neurofibromas are one of the clinical manifestations of NF1, along with other symptoms such as café-au-lait spots (pigmented skin lesions), Lisch nodules (benign eye tumors), bone abnormalities, and an increased risk of developing certain cancers.
Symptoms and severity of multiple neurofibromas can vary widely among individuals. While some may have only a few scattered tumors that cause minimal complications, others may experience significant pain, disfigurement, and functional impairment as a result of the numerous tumors. Regular monitoring of these tumors is essential to detect any signs of malignant transformation or other complications that may require treatment.
Common Misspellings for MULTIPLE NEUROFIBROMA
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Etymology of MULTIPLE NEUROFIBROMA
The word "neurofibroma" is derived from two Greek roots: "neuron", meaning nerve, and "fibroma", meaning a tumor composed of fibrous connective tissue. Neurofibromas are tumors of the peripheral nerves that develop from specialized cells called Schwann cells.
The term "multiple" in "multiple neurofibroma" simply indicates that there is presence of more than one neurofibroma in the affected individual. So the etymology of "multiple neurofibroma" can be understood by looking at the individual components of the word: "multiple" meaning more than one, and "neurofibroma" referring to the type of tumor that arises from nerves and fibrous tissue.
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