MULTICELLULAR SPHEROIDS Meaning and
Definition
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Multicellular Spheroids refer to three-dimensional aggregates of multiple cells, which closely resemble the organization and architecture of tissues found in living organisms. These structures are usually formed in laboratory settings using cell culture techniques to mimic the complex nature of tissues and organs. Multicellular spheroids possess a variety of cell types, resembling in vivo conditions more accurately compared to traditional two-dimensional cell cultures.
These structures are characterized by a core composed of proliferating cells surrounded by quiescent or differentiated outer layers, simulating a hierarchical spatial arrangement reminiscent of tissues. Multicellular spheroids exhibit heterogeneity in terms of cell composition, signaling gradients, and nutrient distribution, closely recapitulating in vivo conditions. This allows researchers to study various cellular processes, including proliferation, differentiation, cell-cell interactions, and drug response in a more physiologically relevant manner than traditional cell culture models.
Multicellular spheroids have gained significant attention in cancer research due to their potential to model solid tumors in a controlled environment. They can be used to investigate tumor behavior, drug delivery mechanisms, and response to therapies. Furthermore, multicellular spheroids have applications in regenerative medicine, toxicity testing, and drug development, providing a more accurate representation of in vivo conditions in preclinical studies.
In summary, multicellular spheroids are artificially constructed three-dimensional aggregates of multiple cells that mimic the architecture and behavior of tissues found in living organisms. They serve as a valuable tool for studying various biological processes and have a wide range of applications in scientific research and clinical settings.
Common Misspellings for MULTICELLULAR SPHEROIDS
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Etymology of MULTICELLULAR SPHEROIDS
The term "multicellular spheroids" does not have a specific etymology as it is a scientific term used to describe a certain type of cellular structure. "Multicellular" refers to an organism or structure composed of multiple cells, while "spheroids" refers to spherical or round shapes. Therefore, the term is a combination of these two concepts to describe a specific cellular arrangement.
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