How Do You Spell ISOCITRATE HYDRO LYASE?

1. Isocitrate hydro lyase, commonly abbreviated as ICL, is an enzyme that plays an important role in cellular metabolism. It belongs to the lyase class of enzymes and is involved in the tricarboxylic acid (TCA) cycle, also known as the citric acid cycle or Krebs cycle.

   Isocitrate hydro lyase catalyzes the cleavage of isocitrate, a key intermediate in the TCA cycle, into glyoxylate and succinate. This reaction is reversible and helps to divert isocitrate away from entering the rest of the TCA cycle, allowing it to enter an alternative pathway known as the glyoxylate cycle. In this pathway, isocitrate is further metabolized to form malate and then oxaloacetate, which can be utilized for the biosynthesis of various compounds such as amino acids and glucose.

   The activity of isocitrate hydro lyase is especially prominent in microorganisms, particularly bacteria and fungi, where it enables them to utilize compounds containing a high carbon-to-oxygen ratio, such as fatty acids and acetate, as a source of carbon and energy. This enzyme provides an important metabolic adaptation for microorganisms living in environments with limited carbon sources, as it allows them to efficiently convert these compounds into usable building blocks for cellular processes.

   In summary, isocitrate hydro lyase is an enzyme that catalyzes the conversion of isocitrate into glyoxylate and succinate, contributing to metabolic pathways such as the glyoxylate cycle. It assists microorganisms in utilizing carbon sources with high carbon-to-oxygen ratios for energy and biosynthesis.

Common Misspellings for ISOCITRATE HYDRO LYASE