FC GAMMA RECEPTORS Meaning and
Definition
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Fc gamma receptors (FcγRs) are a group of cell surface proteins that play a crucial role in the immune response by mediating the binding and activation of antibodies. These receptors are primarily found on the surface of immune cells, including phagocytes (such as neutrophils, macrophages, and dendritic cells) and specialized cells involved in antibody production (such as B cells).
FcγRs belong to the immunoglobulin superfamily and are specific for the Fc region of immunoglobulin G (IgG) antibodies. Binding to the Fc region allows FcγRs to recognize and bind to immune complexes, which are formed when antibodies bind to a target antigen. This interaction triggers a cascade of signaling events within the immune cell, leading to various effector functions crucial for immune defense.
Activation of FcγRs can induce phagocytosis, the process by which immune cells engulf and destroy pathogens or cells labeled with antibodies. Furthermore, FcγRs can stimulate the release of inflammatory mediators, such as cytokines and chemokines, which recruit other immune cells to the site of infection and promote inflammation. They also have a role in antibody-dependent cell-mediated cytotoxicity (ADCC), where immune cells kill target cells coated with antibodies.
The diversity of FcγRs allows for precise regulation of immune responses, as different FcγR subtypes have distinct functions and affinities for IgG subclasses. Dysregulation of FcγR signaling has been implicated in various autoimmune diseases, allergies, and immune deficiencies. Therefore, understanding the biology and functions of FcγRs is crucial for developing therapeutic strategies and modulating immune responses in various diseases.
Common Misspellings for FC GAMMA RECEPTORS
- dc gamma receptors
- cc gamma receptors
- vc gamma receptors
- gc gamma receptors
- tc gamma receptors
- rc gamma receptors
- fx gamma receptors
- fv gamma receptors
- ff gamma receptors
- fd gamma receptors
- fc famma receptors
- fc vamma receptors
- fc bamma receptors
- fc hamma receptors
- fc yamma receptors
- fc tamma receptors
- fc gzmma receptors
- fc gsmma receptors
- fc gwmma receptors
- fc gqmma receptors
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