ASCOLI REACTION Meaning and
Definition
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The Ascoli reaction refers to a chemical transformation known as the Ascoli synthesis, which involves the preparation of pyrimidines. It is a condensation reaction that involves the reaction between α,β-unsaturated methyl ketones and guanidine or its derivatives, commonly amidines or aminoguanidines.
In this reaction, the α,β-unsaturated methyl ketones undergo nucleophilic addition with guanidine or its derivatives, leading to the formation of a substituted imidazolone intermediate. This intermediate then undergoes a subsequent intramolecular condensation reaction, resulting in the formation of the desired pyrimidine compound. The reaction is typically catalyzed by an acid, which facilitates the dehydration step of the imidazolone intermediate.
The Ascoli reaction is widely used in organic synthesis to prepare various pyrimidine derivatives due to its relatively straightforward procedure and broad substrate scope. It offers a versatile method for the construction of pyrimidine frameworks, which are important structural motifs found in numerous bioactive compounds, pharmaceuticals, and natural products.
Overall, the Ascoli reaction is a valuable synthetic tool for the efficient synthesis of pyrimidine compounds, contributing significantly to the development of medicinal chemistry and drug discovery.
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A precipitation test for anthrax; the suspected material is boiled for a few minutes in physiological salt solution which is then filtered, and over it is gently poured a little specific serum; a precipitate occurs at the plane of contact if the material is from a case of anthrax.
A practical medical dictionary. By Stedman, Thomas Lathrop. Published 1920.
Common Misspellings for ASCOLI REACTION
- zscoli reaction
- sscoli reaction
- wscoli reaction
- qscoli reaction
- aacoli reaction
- azcoli reaction
- axcoli reaction
- adcoli reaction
- aecoli reaction
- awcoli reaction
- asxoli reaction
- asvoli reaction
- asfoli reaction
- asdoli reaction
- ascili reaction
- asckli reaction
- asclli reaction
- ascpli reaction
- asc0li reaction
- asc9li reaction
Etymology of ASCOLI REACTION
The term "Ascoli reaction" is named after the Italian chemist and pharmacist Ottaviano Ascoli. Ottaviano Ascoli was born on August 14, 1853, in Ancona, Italy, and died on May 7, 1928. He is known for his contributions to the field of organic chemistry, particularly in the synthesis of heterocyclic compounds. The Ascoli reaction, also referred to as the Ascoli-Aldol reaction, is a reaction in organic chemistry that involves the condensation of an aldehyde or ketone with a β-keto ester to form a new carbon-carbon bond, resulting in the formation of a β-hydroxy ester. The reaction was first described by Ascoli in the late 19th century, and it still bears his name today as a tribute to his work in the field.
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