ALLOGRAFT TOLERANCE Meaning and
Definition
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Allograft tolerance is a term used in transplant medicine to describe a state in which a recipient's immune system accepts and maintains a transplanted organ or tissue without the need for ongoing immunosuppression. It refers to the ability of the recipient's immune system to recognize the transplanted graft as "self" rather than as a foreign entity.
In the context of transplantation, allograft tolerance represents the ideal outcome, as it allows for long-term graft survival without the side effects and risks associated with immunosuppressive medications. Achieving allograft tolerance is a major goal in the field of transplantation, as it would significantly improve the quality of life for transplant recipients and reduce the burden of immune-suppressive therapies.
Several mechanisms contribute to the development of allograft tolerance, including central and peripheral tolerance mechanisms within the recipient's immune system. Central tolerance is achieved through thymic deletion or education of immune cells to recognize and eliminate potentially harmful cells, while peripheral tolerance involves the regulation of immune responses in the periphery.
Inducing allograft tolerance is a complex and multifaceted process that requires a thorough understanding of the interactions between the immune system and the transplanted graft. Research efforts are focused on developing strategies to promote and enhance allograft tolerance, such as co-stimulatory blockade, regulatory T cells, and mixed chimerism approaches, with the ultimate goal of improving graft survival and long-term outcomes in transplantation.
Common Misspellings for ALLOGRAFT TOLERANCE
- zllograft tolerance
- sllograft tolerance
- wllograft tolerance
- qllograft tolerance
- aklograft tolerance
- aplograft tolerance
- aolograft tolerance
- alkograft tolerance
- alpograft tolerance
- aloograft tolerance
- alligraft tolerance
- allkgraft tolerance
- alllgraft tolerance
- allpgraft tolerance
- all0graft tolerance
- all9graft tolerance
- allofraft tolerance
- allovraft tolerance
- allobraft tolerance
- allohraft tolerance
Etymology of ALLOGRAFT TOLERANCE
The word "allograft" is derived from the Greek roots "allo" meaning "other" or "different", and "graft" referring to a transplantation or implantation of tissue. "Tolerance" comes from the Latin root "tolerantia" meaning "endurance" or "patience". So, overall, the term "allograft tolerance" combines these words to describe the acceptance or lack of rejection by a recipient's immune system towards a transplanted tissue or organ from a genetically different individual (usually from the same species).
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